Long‐Term Sequential Therapy for Pregnancy‐ and Lactation‐Associated Osteoporosis With Multiple Vertebral Fractures: A Case Report of Over 5 Years
Kaneyuki Tsuchimochi, Hiroe Tsuchimochi · 2026
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Description
Kaneyuki Tsuchimochi and Hiroe Tsuchimochi report a 2026 case of long-term sequential therapy for pregnancy- and lactation-associated osteoporosis. This rare condition weakens bones during late pregnancy or after delivery and can fracture several vertebrae. Evidence on long-term treatment sequences combining bone-building and bone-protecting drugs is limited.
Their patient was a 37-year-old woman who developed low back pain three months after delivery, with multiple acute and chronic vertebral fractures. Her lumbar spine Z-score stayed low at −3.0 despite early improvement on a bisphosphonate. Therapy then moved in sequence: daily teriparatide for two years, romosozumab for one year, then denosumab for maintenance. Over five years and seven months, bone density rose 53.4% at the spine and 26.1% at the femoral neck. No new fractures occurred. The authors credit shared decision-making and patient education for the sustained gains.
Catalog record
| CREATOR | Kaneyuki Tsuchimochi, Hiroe Tsuchimochi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24461 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |