The complexity of invasive fungal diseases in the intensive care unit: evaluation of metagenomic next-generation sequencing
Rui Wang, Hailing Yang, Chunmei Zhang, Xirenguli Zi Neng · 2026
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Description
Rui Wang and colleagues assessed in 2026 whether gene sequencing of patient samples helps diagnose invasive fungal infections in intensive care. Many such infections strike patients without the classic risk factors, and standard tests miss fungi often. Their review covered 106 adults treated between mid-2022 and early 2025, split by immune status.
Two thirds of the patients had working immune systems, though many carried other illnesses. Sequencing found most of the 81 pathogens identified overall and excelled at rare fungi and mixed infections where standard tests fell short. Its results changed care for seventy-five patients, about seven in ten. Fluid washed from the lungs gave the most useful samples, while blood gave the least. The authors back sequencing as a strong add-on, with specimen choice shaping the benefit.
Catalog record
| CREATOR | Rui Wang, Hailing Yang, Chunmei Zhang, Xirenguli Zi Neng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |