Strategies for Enhancing Selectivity in Anticancer Metal Complexes
Paolo R. Butcher, Daniel Sykes · 2026
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Description
Paolo R Butcher and Daniel Sykes reviewed in 2026 how chemists make metal-based cancer drugs hit tumors while sparing healthy tissue. Platinum drugs such as cisplatin work, yet their poor aim causes severe side effects and invites resistance. Their review sorts the known remedies into eight strategy families.
Passive targeting leans on leaky tumor vessels, while active targeting adds homing molecules that bind cancer markers. Other families make the drug wake up only under tumor-like conditions or under outside triggers such as light. Structural tweaks, delivery vehicles, and aiming at compartments inside the cell round out the toolkit. Each section weighs the science, examples, strengths, and limits of its family. The authors aim to give designers a single map for building the next generation of selective metal drugs.
Catalog record
| CREATOR | Paolo R. Butcher, Daniel Sykes |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |