Synchronizing the Osteochondral Regeneration Process through Spatial Patterning of Stable and Hypertrophic Cartilage Organoids
Liuqi Peng, Isaak Decoene, Hanna Svitina, Ioannis Papantoniou · 2026
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Description
Peng, Decoene, Svitina, and Papantoniou join cell clusters to heal deep joint defects. Such defects harm both cartilage and the bone beneath it. Cartilage cannot regrow well on its own. The team grew two organoid types with no scaffold. One came from stem-cell-derived cartilage cells, and one from periosteum cells.
Joined clusters formed zones like real joint tissue. A cartilage-rich zone and a bone-like zone met at a clear border. Matrix laid itself down without outside cues. Placed in rat defects, the clusters aided smooth cartilage repair. Bone formed beneath while the seam held its layered order.
Catalog record
| CREATOR | Liuqi Peng, Isaak Decoene, Hanna Svitina, Ioannis Papantoniou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |