Dual targeting of mitochondrial metabolism and Rho GTPase signaling to suppress cancer metastasis (Review)
Angelina Daher, Zahraa Assi, Amjad Kanaan, Ahmad Al Khatib, Mirvat El Sibai · 2026
Read Dual targeting of mitochondrial metabolism and Rho GTPase signaling to suppress cancer metastasis (Review) by Angelina Daher, Zahraa Assi, Amjad Kanaan, Ahmad Al Khatib, Mirvat El Sibai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13261337.txt.
Description
Angelina Daher and co-authors argue that stopping cancer spread means cutting both its engine and its fuel. Metastasis demands energy and shape-shifting at once, supplied by mitochondria and Rho GTPase switches working as one system. Their 2026 review maps the two-way traffic between them.
Mitochondria hand ATP and reactive oxygen to Rho signaling, powering invasion machinery. In return, cytoskeletal remodeling drags mitochondria where energy is needed most, reinforcing the loop. Hitting either side alone invites the other to compensate, they contend. Their prescription pairs gene silencing of Rho switches with mitochondria-blocking repurposed antibiotics, aiming to collapse the partnership outright.
Catalog record
| CREATOR | Angelina Daher, Zahraa Assi, Amjad Kanaan, Ahmad Al Khatib, Mirvat El Sibai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |