LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability
Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang · 2026
Read LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability by Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13261336.txt.
Description
Lizhong Zeng and colleagues expose a long RNA that helps lung adenocarcinoma cells multiply. LINC01117 is barely present in healthy lung but climbs in these tumors, in step with worse survival. Their 2026 study silences and boosts it in cancer cells to see what changes.
Silencing slowed proliferation sharply, while boosting sped it, across several growth assays. The RNA's partner proved to be HOXD8, a developmental transcription factor whose message it stabilizes. Cells lost their growth advantage when HOXD8 was removed, even with LINC01117 turned high. Blocking transcription showed the RNA works by extending HOXD8's messenger lifespan, making the pair a candidate biomarker and target.
Catalog record
| CREATOR | Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |