Acylglycerol kinase contributes to cell proliferation by activating NF-κB signaling pathway in pancreatic cancer
Kunkun Han, Qianyun Zhang, Shengnan Gao, Jigang Zhang, Xiao Mei, Fei Li, Xin Xu, Shu Li, Guodong Chen · 2026
Read Acylglycerol kinase contributes to cell proliferation by activating NF-κB signaling pathway in pancreatic cancer by Kunkun Han, Qianyun Zhang, Shengnan Gao, Jigang Zhang, Xiao Mei, Fei Li, Xin Xu, Shu Li, Guodong Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13261334.txt.
Description
Kunkun Han and colleagues examined in 2026 a fat-processing enzyme called acylglycerol kinase in pancreatic cancer. Pancreatic cancer kills most patients within a short time, largely because it is found late and resists treatment. Their laboratory work compared cancer tissue and cell lines with normal counterparts using gene and protein tests.
The enzyme was markedly more abundant in cancer samples, and higher levels tracked with poorer patient outlook. Turning the gene down slowed cancer cell growth, while forcing it up sped growth through known proliferation genes. The enzyme switched on the NF-kB signaling pathway by moving its p65 part into the cell nucleus. High enzyme levels also blunted the effect of drugs and radiation on the cells. The authors name the enzyme a possible drug target and diagnostic marker.
Catalog record
| CREATOR | Kunkun Han, Qianyun Zhang, Shengnan Gao, Jigang Zhang, Xiao Mei, Fei Li, Xin Xu, Shu Li, Guodong Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |