GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi
Julian Nüchel, Maryam Omidi, Stephanie A Fernandes, Marina Tauber, Sandra Pohl, Markus Plomann, Constantinos Demetriades · 2026
Read GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi by Julian Nüchel, Maryam Omidi, Stephanie A Fernandes, Marina Tauber, Sandra Pohl, Markus Plomann, Constantinos Demetriades (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13261057.txt.
Description
Julian Nüchel and co-authors show that a Golgi protein called GRASP55 keeps the cell's recycling centers working, in this 2026 paper. Lysosomes digest waste and send signals, and they depend on enzymes sorted at the Golgi. How the two organelles stay linked was unclear.
Removing GRASP55, but not its twin GRASP65, made cells misroute and spill their lysosomal enzymes. The organelles swelled and a key growth signal pathway dimmed. The protein holds a partner at the Golgi that supports the tagging system marking enzymes for delivery. The findings tie Golgi sorting directly to lysosome health and signaling.
Catalog record
| CREATOR | Julian Nüchel, Maryam Omidi, Stephanie A Fernandes, Marina Tauber, Sandra Pohl, Markus Plomann, Constantinos Demetriades |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |