Cellular mechanometabolism: stimuli and implications
Ismael Ortiz, Santiago Lopez, Raghu Vamsi Kondapaneni, Jose V Hernandez, Keefer Boone, Cynthia A Reinhart-King · 2026
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Description
Ismael Ortiz and co-authors review a young field joining force and fuel use inside cells, in a 2026 paper. Cells read not only chemicals around them but also pull, squeeze, and shear from their setting. Those forces meet the cell's energy machinery and can change how it grows, moves, and divides. The field's name for this cross-talk is cellular mechanometabolism.
The review walks through how grip on the matrix and forces like flow and stretch reset a cell's energy needs. It weighs what this means for healthy tissue balance and for disease, where stiff or strained settings are common. The authors argue that grasping force-fuel links may open fresh treatment angles. The field now needs sharper tools to test the links in living tissue.
Catalog record
| CREATOR | Ismael Ortiz, Santiago Lopez, Raghu Vamsi Kondapaneni, Jose V Hernandez, Keefer Boone, Cynthia A Reinhart-King |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |