Overlap of PR3-Positive ANCA-Associated Vasculitis and Primary Focal Segmental Glomerulosclerosis: A Case Report, Patient Perspective, and Review of the Literature
Adina Landsberg, Dale E. Marzolf, Simon R. Walker, Kim Cheema, Tyrone G. Harrison · 2026
Read Overlap of PR3-Positive ANCA-Associated Vasculitis and Primary Focal Segmental Glomerulosclerosis: A Case Report, Patient Perspective, and Review of the Literature by Adina Landsberg, Dale E. Marzolf, Simon R. Walker, Kim Cheema, Tyrone G. Harrison (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13260775.txt.
Description
Adina Landsberg and colleagues present a 2026 case report, with literature review and patient perspective, of two kidney diseases occurring together. A 63-year-old man arrived with four weeks of body-wide swelling and months of cognitive changes, blurry vision, and tingling. Tests showed heavy protein loss in urine at 8.25 grams per day, low blood protein, blood in urine, acute kidney injury, and high blood pressure. Kidney biopsy revealed both diseases at once.
One disease was focal segmental glomerulosclerosis, a scarring of the kidney's filters. The other was ANCA-associated vasculitis, an immune vessel inflammation confirmed by a positive PR3 antibody test. Treatment combined steroids and rituximab for the vasculitis, then calcineurin inhibitor drugs for the resistant scarring disease, plus kidney-protective medicines. After two and a half years he reached partial remission, though kidney function stayed reduced and treatment caused diabetes.
Catalog record
| CREATOR | Adina Landsberg, Dale E. Marzolf, Simon R. Walker, Kim Cheema, Tyrone G. Harrison |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20740 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |