Cross‐Compartment Multimodal Analyses Reveal Differences in IL2‐STAT5 Signaling Associated With Asthma in Individuals From Diverse Backgrounds
Duan Ni, Ralph Nanan · 2026
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Description
Duan Ni and Ralph Nanan present a 2026 study of immune signalling differences linked to asthma across self-reported racial backgrounds. People from non-European backgrounds are underrepresented in asthma research. The team ran multimodal analyses, combining several single-cell and protein measurement methods, across airway tissue, blood, and immune cells from healthy people and asthma patients. Their focus was the IL2-STAT5 pathway, a signalling route central to asthma biology and T cell activation.
During asthma, self-reported African American patients showed higher IL2-STAT5 signalling across bronchial and airway tissue, circulating T cells, whole blood, and blood immune cells. This tracked with increased T cell activation and recruitment. Healthy African American participants also showed elevated signalling compared with European American participants, suggesting a possible predisposition. The authors stress the need for larger, more diverse cohorts before clinical use.
Catalog record
| CREATOR | Duan Ni, Ralph Nanan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36669 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |