Progress and prospects for herpesvirus vaccination using gB antigens
Solomon English, Adam Khan-Qureshi, Alexander D. Douglas · 2026
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Description
Solomon English, Adam Khan-Qureshi, and Alexander D Douglas reviewed in 2026 the case for building herpesvirus vaccines around the glycoprotein B antigen. Herpesviruses invade cells by fusing their envelope with the cell membrane, and glycoprotein B drives that fusion across the whole family. Working vaccines exist only for the chickenpox and shingles virus, leaving Epstein-Barr virus, cytomegalovirus, and herpes simplex viruses uncovered.
A glycoprotein B vaccine against cytomegalovirus already showed partial protection in trials, which encourages better versions. Recent work has stabilized the protein in its pre-fusion shape, the form thought most useful for training immunity. The review covers the protein's structure, antibody studies in the laboratory, and past animal and human vaccine results. The authors weigh this route against rival antigens and argue it deserves renewed attention.
Catalog record
| CREATOR | Solomon English, Adam Khan-Qureshi, Alexander D. Douglas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |