Effects of flavonoids on atherosclerosis in ApoE−/− mice: a systematic review and meta-analysis
Peiqi Gao, Man Gong, Junchao Wu, Songru Guo, Shuni He, Chengfu Su · 2026
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Description
Peiqi Gao and colleagues combined in 2026 the animal evidence on flavonoids, plant compounds, against artery-clogging disease. Their systematic review and meta-analysis gathered studies in ApoE-deficient mice, a standard model of atherosclerosis. Eleven studies qualified, all using male mice.
Across studies, flavonoid treatment lowered the harmful blood fats LDL cholesterol, total cholesterol, and triglycerides. It also raised protective HDL cholesterol. Every included study reported smaller plaque areas in the aorta of treated mice. The authors link the benefit to lipid control plus antioxidant and anti-inflammatory actions. Results varied a lot between studies, though, and signs of publication bias appeared for most fat measures. They call for more uniform, high-quality animal work before any move toward patient trials.
Catalog record
| CREATOR | Peiqi Gao, Man Gong, Junchao Wu, Songru Guo, Shuni He, Chengfu Su |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |