Structural and functional hepatic factors as prognostic indicators in children with Langerhans cell histiocytosis
Seham Hassan, Mohamed Sedky M Sedky, Asmaa Salama, Iman Zaky, Hany Girguis, Salma Abd ELKarim, Alaa ELHaddad · 2026
Read Structural and functional hepatic factors as prognostic indicators in children with Langerhans cell histiocytosis by Seham Hassan, Mohamed Sedky M Sedky, Asmaa Salama, Iman Zaky, Hany Girguis, Salma Abd ELKarim, Alaa ELHaddad (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13259843.txt.
Description
Seham Hassan and co-authors studied in 2026 which liver findings predict outcomes for children with Langerhans cell histiocytosis. This rare blood cell disorder can involve the liver, and liver involvement is usually classed as high risk. Their review covered 453 children treated at a cancer hospital in Egypt between 2007 and 2021.
Eighty children had liver involvement: 27 had an enlarged liver with normal function, and 53 had liver dysfunction. Children with dysfunction failed early treatment far more often and had much worse five-year survival than those with enlargement alone. Low blood albumin also marked poorer outcomes, while liver size by itself did not predict the course. The authors suggest risk groups should rest on liver function rather than size alone.
Catalog record
| CREATOR | Seham Hassan, Mohamed Sedky M Sedky, Asmaa Salama, Iman Zaky, Hany Girguis, Salma Abd ELKarim, Alaa ELHaddad |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |