Nitric oxide-driven Warburg reprogramming at the NOS2-COX2 axis: An integrative engine of cancer hallmarks
Leandro L. Coutinho, Erika M. Palmieri, Lisa A. Ridnour, Robert Y.S. Cheng, William F. Heinz, Stephen K. Anderson, Timothy R. Billiar, Jenny Chang, Stephen J. Lockett, M. Cristina Rangel, Douglas D. Thomas, Daniel W. McVicar, David A. Wink · 2026
Read Nitric oxide-driven Warburg reprogramming at the NOS2-COX2 axis: An integrative engine of cancer hallmarks by Leandro L. Coutinho, Erika M. Palmieri, Lisa A. Ridnour, Robert Y.S. Cheng, William F. Heinz, Stephen K. Anderson, Timothy R. Billiar, Jenny Chang, Stephen J. Lockett, M. Cristina Rangel, Douglas D. Thomas, Daniel W. McVicar, David A. Wink (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13259629.txt.
Description
Leandro L. Coutinho and coauthors map how nitric oxide locks advanced cancers into sugar burning metabolism in a 2026 review. Two inflammation enzymes cooperate to sustain that state in tumors and their support cells. Early macrophage work showed nitric oxide blocking energy production in neighboring cells.
At signaling levels, the gas disables key steps of oxygen based energy release. Cells shift toward fast glycolysis, glutamine use, and protective reducing power. Chemical locks on gene control then stabilize the cancer program. The two enzymes feed each other in a self strengthening circuit. Cancer biologists gain an integrated engine model linking inflammation to tumor metabolism.
Catalog record
| CREATOR | Leandro L. Coutinho, Erika M. Palmieri, Lisa A. Ridnour, Robert Y.S. Cheng, William F. Heinz, Stephen K. Anderson, Timothy R. Billiar, Jenny Chang, Stephen J. Lockett, M. Cristina Rangel, Douglas D. Thomas, Daniel W. McVicar, David A. Wink |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 115 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |