Pharmacological inhibition of LIF signaling reverses PD-L1-mediated immune suppression in gastric cancer
Cristina Di Giorgio, Silvia Marchianò, Michele Biagioli, Ginevra Lachi, Carmen Massa, Benedetta Sensini, Eleonora Giannelli, Maria Rosaria Sette, Ginevra Urbani, Francesca Paniconi, Luigi Cari, Maria Chiara Monti, Valentina Sepe, Nicola Natalizi, Luigina Graziosi, Eleonora Distrutti, Annibale Donini · 2026
Read Pharmacological inhibition of LIF signaling reverses PD-L1-mediated immune suppression in gastric cancer by Cristina Di Giorgio, Silvia Marchianò, Michele Biagioli, Ginevra Lachi, Carmen Massa, Benedetta Sensini, Eleonora Giannelli, Maria Rosaria Sette, Ginevra Urbani, Francesca Paniconi, Luigi Cari, Maria Chiara Monti, Valentina Sepe, Nicola Natalizi, Luigina Graziosi, Eleonora Distrutti, Annibale Donini (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13259620.txt.
Description
Cristina Di Giorgio and co-authors finger a cytokine that helps stomach tumors hide from the immune system. Leukemia inhibitory factor, or LIF, was unexplored in gastric cancer's use of the PD-L1 shield. Their 2026 study measures both molecules in removed tumors and tests a LIF-blocking drug candidate.
Tumor LIF ran high and tracked with more PD-L1 and worse survival. Through a JAK and STAT3 relay, LIF ordered cells to make more PD-L1 and turn invasive. The antagonist LRI-305 cut that signal, lowered PD-L1, and partly woke immune activity back up. Pairing LIF blockade with checkpoint immunotherapy is their proposed next step.
Catalog record
| CREATOR | Cristina Di Giorgio, Silvia Marchianò, Michele Biagioli, Ginevra Lachi, Carmen Massa, Benedetta Sensini, Eleonora Giannelli, Maria Rosaria Sette, Ginevra Urbani, Francesca Paniconi, Luigi Cari, Maria Chiara Monti, Valentina Sepe, Nicola Natalizi, Luigina Graziosi, Eleonora Distrutti, Annibale Donini |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |