Posterior shift of Shh-Fgf signaling in axolotl limb regeneration drives sequential digit formation
Saya Furukawa, Sakiya Yamamoto, Haruki Nakayama, Ayaka Ohashi, Akira Satoh · 2026
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Description
Saya Furukawa and colleagues watch a salamander regrow its hand and find the instructions move. Axolotls rebuild limbs using the same SHH and FGF8 signals other vertebrates use, but deployed in a different place. Their 2026 study tracks the signaling loop as digits appear.
Instead of staying put, the loop's active zone slides steadily toward the rear of the growing limb. Digits are switched on one after another as it passes, back to front. That is the reverse of the amniote order, yet the finished limb looks the same. Conserved toolkits, they conclude, can reach one shape by different routes.
Catalog record
| CREATOR | Saya Furukawa, Sakiya Yamamoto, Haruki Nakayama, Ayaka Ohashi, Akira Satoh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |