The PI3K/AKT signaling networks in cancer glucose metabolism: mechanisms and therapeutic implications
Sufen Cheng, Qi Jiang, Hua Huang, Hongyan Tong, Mixue Xie · 2026
Read The PI3K/AKT signaling networks in cancer glucose metabolism: mechanisms and therapeutic implications by Sufen Cheng, Qi Jiang, Hua Huang, Hongyan Tong, Mixue Xie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13259617.txt.
Description
Sufen Cheng and co-authors review how one signaling axis teaches cancer cells to gorge on glucose. The PI3K/AKT pathway sits at the center of growth control and is often jammed on in tumors. Their 2026 review maps its grip on sugar metabolism step by step.
The pathway directs core enzymes of glycolysis, from hexokinase to lactate dehydrogenase, including some moonlighting jobs those enzymes secretly perform. It also negotiates with the cell's energy sensor and with fat-building and phosphate pathways. Blocking the axis to starve tumors is promising but tricky, the authors show. They close with combination therapy ideas and the hurdles ahead.
Catalog record
| CREATOR | Sufen Cheng, Qi Jiang, Hua Huang, Hongyan Tong, Mixue Xie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |