Identifying Conserved Regions in HIV-1 Proteins by Entropy Analysis of Sequence Variability
Alexandr N. Shchemelev, Elena N. Serikova, Yulia V. Ostankova, Vladimir S. Davydenko, Edward S. Ramsay, Areg A. Totolian · 2026
Read Identifying Conserved Regions in HIV-1 Proteins by Entropy Analysis of Sequence Variability by Alexandr N. Shchemelev, Elena N. Serikova, Yulia V. Ostankova, Vladimir S. Davydenko, Edward S. Ramsay, Areg A. Totolian (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13257677.txt.
Description
Alexandr Shchemelev and colleagues hunt for the parts of HIV-1 that barely change, however much the virus mutates elsewhere. Stable regions matter because they keep the virus working and could anchor future drugs or vaccines. Their 2026 study scores conservation across every major viral protein.
They analyzed more than a thousand full viral genomes spanning the main subtypes. An entropy score flagged columns where sequences stayed nearly identical, and two search methods mapped the conserved stretches. The Pol and Gag proteins held the most, including enzyme centers and binding sites. The authors present these stretches as candidate targets needing lab validation.
Catalog record
| CREATOR | Alexandr N. Shchemelev, Elena N. Serikova, Yulia V. Ostankova, Vladimir S. Davydenko, Edward S. Ramsay, Areg A. Totolian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |