Severe Metabolic Decompensation in Metastatic Sarcomatoid Renal Cell Carcinoma During Immune Checkpoint Inhibitor Therapy: A Case Report and Literature Review
Lorena Ciumărnean, Cezara Andreea Gerdanovics, Olga Hilda Orășan, Alexandru Gerdanovics, Nicoleta Valentina Leach, Ioana Para, Gabriela Bombonica Dogaru · 2026
Read Severe Metabolic Decompensation in Metastatic Sarcomatoid Renal Cell Carcinoma During Immune Checkpoint Inhibitor Therapy: A Case Report and Literature Review by Lorena Ciumărnean, Cezara Andreea Gerdanovics, Olga Hilda Orășan, Alexandru Gerdanovics, Nicoleta Valentina Leach, Ioana Para, Gabriela Bombonica Dogaru (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13257411.txt.
Description
Lorena Ciumărnean and co-authors present a 2026 case report of severe metabolic collapse during kidney cancer care. A fifty-four-year-old woman had metastatic clear cell kidney cancer with sarcomatoid features, an aggressive variant. Earlier checkpoint therapy had already caused gland inflammation and thyroid failure before later drug treatment.
She arrived dehydrated with repeated vomiting, deep weakness, and dangerous blood chemistry, including high potassium, low sodium, and low sugar. Kidney injury and low blood counts compounded the picture. Fluids, electrolyte correction, and supportive care restored chemistry and kidney function. Muscle weakness raised concern for an immune nerve or muscle event, though potassium alone could explain part of it. Oncologists get a warning case on layered toxicity. Careful differential diagnosis and team management are the authors' central plea.
Catalog record
| CREATOR | Lorena Ciumărnean, Cezara Andreea Gerdanovics, Olga Hilda Orășan, Alexandru Gerdanovics, Nicoleta Valentina Leach, Ioana Para, Gabriela Bombonica Dogaru |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |