Reading Between the ABCs: Intrinsic Disorder and Evolutionary Dynamics of Non-Canonical Regions in ABC Transporters
Ichda Arini Dinana, Yukihiko Kubota, Masahiro Ito · 2026
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Description
Ichda Arini Dinana, Yukihiko Kubota, and Masahiro Ito published a 2026 study on the floppy parts of ABC transporters. These proteins ferry substances across cell membranes and form one of the largest protein families. Their neat folded domains are well studied, but the loose regions between domains are not.
The team checked 1,581 transporter sequences from bacteria to complex life. They split the proteins into five build types. Linker and edge regions proved far more disordered than the core domains in every type. They also mapped signs of selection pressure and likely chemical tag sites. Loose regions may tune how each transporter works, and their record across lineages hints at hidden roles.
Catalog record
| CREATOR | Ichda Arini Dinana, Yukihiko Kubota, Masahiro Ito |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |