Evaluating a Coenzyme Q10-Based Food for Special Medical Purpose, for Mitochondrial Diseases Management: An Open-Label, Pilot Trial
Lucia Chico, Piervito Lopriore, Giulia Cecchi, Adriana Meli, Clara Bernardini, Linda Balestrini, Maico Polzella, Vincenzo Montano, Michelangelo Mancuso · 2026
Read Evaluating a Coenzyme Q10-Based Food for Special Medical Purpose, for Mitochondrial Diseases Management: An Open-Label, Pilot Trial by Lucia Chico, Piervito Lopriore, Giulia Cecchi, Adriana Meli, Clara Bernardini, Linda Balestrini, Maico Polzella, Vincenzo Montano, Michelangelo Mancuso (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13257338.txt.
Description
Chico and colleagues ran a small open-label pilot trial of a high-dose coenzyme Q10 medical food in primary mitochondrial disease, conditions with few treatment options. Ten patients took the preparation, at two hundred fifty or five hundred milligrams daily, for thirty days after a month on conventional coenzyme Q10. Blood biomarkers, fatigue scores, and a sit-to-stand test were measured before and after.
Every patient kept blood coenzyme Q10 above a target threshold on the new preparation, versus sixty percent before, and dose-normalized exposure rose sharply. One antioxidant capacity measure improved, while disease biomarkers, fatigue, and sit-to-stand performance did not change significantly. The authors call the simplified dosing promising for adherence and seek larger trials.
Catalog record
| CREATOR | Lucia Chico, Piervito Lopriore, Giulia Cecchi, Adriana Meli, Clara Bernardini, Linda Balestrini, Maico Polzella, Vincenzo Montano, Michelangelo Mancuso |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |