Transcriptomic Signature of PDGF-BB Control of Annulus Fibrosus Reveals Modulation of Inflammatory and Neurogenic Pathways
Changli Zhang, Gilbert Gu, Joshua W. McNulty, David Berenfeld, Lisbet Haglund, Sangwook Tim Yoon, Brian Goh, Hicham Drissi · 2026
Read Transcriptomic Signature of PDGF-BB Control of Annulus Fibrosus Reveals Modulation of Inflammatory and Neurogenic Pathways by Changli Zhang, Gilbert Gu, Joshua W. McNulty, David Berenfeld, Lisbet Haglund, Sangwook Tim Yoon, Brian Goh, Hicham Drissi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13257205.txt.
Description
Changli Zhang and co-authors profile gene activity in human disc cells treated with a growth factor in a 2026 study. Low back pain links closely to disc degeneration, where inflammation in the outer ring helps generate pain. PDGF-BB is known for tissue repair, yet its disc effects were unclear.
Healthy and degenerated ring cells received the factor for three or five days before RNA sequencing. Cell division, matrix rebuilding, inflammation, and nerve-related genes all shifted. A strong inflammatory signal raised pain mediators such as nerve growth factor and interleukins, while PDGF-BB suppressed those responses. Public single-cell data anchored the lab findings to real tissue. Back researchers gain a gene-level foundation for testing disc repair ideas. Any therapy remains distant, and animal work comes first.
Catalog record
| CREATOR | Changli Zhang, Gilbert Gu, Joshua W. McNulty, David Berenfeld, Lisbet Haglund, Sangwook Tim Yoon, Brian Goh, Hicham Drissi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |