Structure–Activity Relationship of Flavonol O-Methylation Revealed by In Vitro, In Silico and Zebrafish Neurodegeneration Models
Kamila Borowiec, Agnieszka Michalak, Katarzyna Targowska-Duda · 2026
Read Structure–Activity Relationship of Flavonol O-Methylation Revealed by In Vitro, In Silico and Zebrafish Neurodegeneration Models by Kamila Borowiec, Agnieszka Michalak, Katarzyna Targowska-Duda (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13257096.txt.
Description
Kamila Borowiec leads a 2026 study of two changed forms of quercetin, a plant pigment in foods. Adding one methyl group at unlike spots can change what the molecule does. The two forms, isorhamnetin and rhamnetin, were tested in dishes, in computer models, and in young zebrafish.
Four bench tests gauged how well each form mops up harmful oxygen forms. Rhamnetin scored higher in three of them. Isorhamnetin blocked an enzyme tied to pain and swelling more strongly, and models showed a unlike grip in the enzyme pocket. Young fish bore rhamnetin better at high doses. Both forms eased movement loss in a toxin model of nerve decay. The lesson is plain: where the group sits shapes both gain and risk.
Catalog record
| CREATOR | Kamila Borowiec, Agnieszka Michalak, Katarzyna Targowska-Duda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |