Pro-Oncogenic Transcription Factors BACH1 and Nrf2 Associate with Cytoplasmic Biomolecular Condensates of GFP-MxA (Myxovirus Resistance Protein A) in Oral Cancer Cells
Pravin B. Sehgal, Huijuan Yuan · 2026
Read Pro-Oncogenic Transcription Factors BACH1 and Nrf2 Associate with Cytoplasmic Biomolecular Condensates of GFP-MxA (Myxovirus Resistance Protein A) in Oral Cancer Cells by Pravin B. Sehgal, Huijuan Yuan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256962.txt.
Description
Pravin B. Sehgal and Huijuan Yuan report a 2026 study of protein droplets inside oral cancer cells. Such droplets, called biomolecular condensates, can gather signaling proteins in one place. Their focus is a tagged form of MxA, a human protein that responds to interferons.
Proteomics of isolated droplets found two cancer-linked transcription factors, BACH1 and Nrf2, along with heme oxygenase 1. Shifting cells between dilute and normal fluid broke the droplets apart and then let them reform. A dietary compound, sulforaphane, also dissolved them. Because BACH1 and Nrf2 control antioxidant defenses, their presence hints at a stress-sensing hub. Cancer biologists get a new structure to probe when studying how oral tumors handle stress.
Catalog record
| CREATOR | Pravin B. Sehgal, Huijuan Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |