Molecular Engineering of Nicotinamide Riboside Kinase and Process Optimization for Efficient Nicotinamide Mononucleotide Production
Dai Ma, Rui Liu, Tong Bao, Jingwen Yang, Hongbin Zhang, Xueqin Hu · 2026
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Description
Dai Ma leads a 2026 enzyme engineering study aimed at making nicotinamide mononucleotide, known as NMN, more efficiently. NMN helps the body make NAD+, a molecule needed for energy and repair. The work centers on an enzyme called nicotinamide riboside kinase.
A redesigned variant of the enzyme doubled its activity and lasted twice as long at warm temperature. Careful tuning of reaction conditions then pushed NMN yield above ninety-four percent. Adding a second enzyme to recycle ATP, the cell energy carrier, lifted yield still higher at a stronger feed level. Readers interested in greener manufacturing get a concrete route toward larger-scale production. The results also show how small protein changes can improve an industrial process.
Catalog record
| CREATOR | Dai Ma, Rui Liu, Tong Bao, Jingwen Yang, Hongbin Zhang, Xueqin Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |