Subthreshold Thermal Stress Aggravates Methamphetamine-Induced Cardiomyocyte Pyroptosis via the Mitochondrial ROS/BAX/mtDNA/NLRP3 Pathway
Mengmeng Wang, Congcong Hou, Menglian Hu, Dan Zhou, Xintao Wang, Mingyang Jin, Chunling Ma, Jianhong Shi, Zhiyu Ni · 2026
Read Subthreshold Thermal Stress Aggravates Methamphetamine-Induced Cardiomyocyte Pyroptosis via the Mitochondrial ROS/BAX/mtDNA/NLRP3 Pathway by Mengmeng Wang, Congcong Hou, Menglian Hu, Dan Zhou, Xintao Wang, Mingyang Jin, Chunling Ma, Jianhong Shi, Zhiyu Ni (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256843.txt.
Description
Mengmeng Wang and co-authors show in a 2026 study that mild heat stress makes methamphetamine far more damaging to heart muscle cells. Their setup models the crowded, hot settings where the drug is often used. Methamphetamine heart injury is a leading cause of death among users beyond overdose, yet environmental factors in that injury are rarely studied.
Mice exposed to methamphetamine at 28 °C fared worse than those at 22 °C, with stronger heart dysfunction and mitochondrial damage. The chain ran from excess mitochondrial reactive oxygen through the protein BAX to leaked mitochondrial DNA that triggered inflammasome-driven cell death. A mitochondria-targeted antioxidant blocked the aggravation, pointing to mitochondrial redox control as a treatment angle.
Catalog record
| CREATOR | Mengmeng Wang, Congcong Hou, Menglian Hu, Dan Zhou, Xintao Wang, Mingyang Jin, Chunling Ma, Jianhong Shi, Zhiyu Ni |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |