Sulforaphane Enhances Cytotoxic Effects of Non-Thermal Plasma and Tirapazamine Combination Therapy in Pancreatic Adenocarcinoma Cells
Ishfar Shaan, Brandon Gulledge, Maksym Poplavskyi, Michelle Eubank, Anastasiia Domukhovska, Anya Weinrieb, Dilbar Alseid, Isabelle Prentice, Samuel Rosen, Gamal Rayan, Shoshanna N. Zucker · 2026
Read Sulforaphane Enhances Cytotoxic Effects of Non-Thermal Plasma and Tirapazamine Combination Therapy in Pancreatic Adenocarcinoma Cells by Ishfar Shaan, Brandon Gulledge, Maksym Poplavskyi, Michelle Eubank, Anastasiia Domukhovska, Anya Weinrieb, Dilbar Alseid, Isabelle Prentice, Samuel Rosen, Gamal Rayan, Shoshanna N. Zucker (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256839.txt.
Description
Ishfar Shaan and co-authors test in a 2026 cell study a three-way combination against pancreatic adenocarcinoma. They pair non-thermal plasma with the hypoxia-activated drug tirapazamine and ask whether sulforaphane, a plant compound from cruciferous vegetables, strengthens the attack. Pancreatic cancer resists most treatments, so combinations that kill through several mechanisms are in demand.
Plasma and tirapazamine each killed cancer cells alone and worked still better as a pair, cutting viability by 87 percent in pre-metastatic cells and nearly eliminating metastatic ones. Adding sulforaphane at 10 μM deepened the killing under every setup, with additive to synergistic interactions. The treatments did not push surviving cells toward a more invasive state, backing further study of the combination.
Catalog record
| CREATOR | Ishfar Shaan, Brandon Gulledge, Maksym Poplavskyi, Michelle Eubank, Anastasiia Domukhovska, Anya Weinrieb, Dilbar Alseid, Isabelle Prentice, Samuel Rosen, Gamal Rayan, Shoshanna N. Zucker |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |