Canonical Pathways Rewiring in Alzheimer’s Disease
Alejandro Pinta-Castro, Gabriela Michel-Ureña, Alejandra Paulina Pérez-González, Guillermo De Anda-Jáuregui, Enrique Hernández-Lemus · 2026
Read Canonical Pathways Rewiring in Alzheimer’s Disease by Alejandro Pinta-Castro, Gabriela Michel-Ureña, Alejandra Paulina Pérez-González, Guillermo De Anda-Jáuregui, Enrique Hernández-Lemus (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256824.txt.
Description
Alejandro Pinta-Castro and co-authors apply network analysis in a 2026 study of Alzheimer's disease. They ask how the co-expression structure of genes in the brain's dorsolateral prefrontal cortex changes as the disease rewires molecular pathways. Instead of single genes, they treat the disease as a breakdown in how gene groups work together.
Building disease-specific networks from bulk RNA sequencing, they found communities enriched for GABA signaling, synapse assembly, and cell adhesion pathways. Key synaptic genes such as NRXN2 and SHANK1 became more central while their modules were broadly turned down. Distances within pathways lengthened across the board, a sign of loosened coordination. The authors read late-onset Alzheimer's as active structural rewiring gathered around synapses.
Catalog record
| CREATOR | Alejandro Pinta-Castro, Gabriela Michel-Ureña, Alejandra Paulina Pérez-González, Guillermo De Anda-Jáuregui, Enrique Hernández-Lemus |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |