Effect of the JAK Inhibitor Baricitinib on Cytokine Production and Bone Properties in a Mouse Model of Accelerated Aging
Katharina Gelles, Vincent Kurz, Maria Butylina, Katharina Wahl-Figlash, Martin Schepelmann, Anastasia Meshcheryakova, Peter Pietschmann · 2026
Read Effect of the JAK Inhibitor Baricitinib on Cytokine Production and Bone Properties in a Mouse Model of Accelerated Aging by Katharina Gelles, Vincent Kurz, Maria Butylina, Katharina Wahl-Figlash, Martin Schepelmann, Anastasia Meshcheryakova, Peter Pietschmann (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256813.txt.
Description
Katharina Gelles and colleagues report in 2026 a mouse study of baricitinib, a JAK inhibitor used for inflammatory diseases, asking whether its cytokine suppression also helps bones weakened by aging. They used SAMP8 mice, a strain that ages quickly, since age-related osteoporosis still lacks enough treatment options.
Sixty eight-month-old females received baricitinib or vehicle by mouth twice daily for six weeks, after which the team measured bone structure and immune cell cytokine production. The drug clearly lowered several inflammatory cytokines from T cells. Bone results were mixed: one measurement method showed higher bone volume while high-resolution scans showed no clear difference. The authors conclude that aged bone responds sluggishly even when inflammation is controlled.
Catalog record
| CREATOR | Katharina Gelles, Vincent Kurz, Maria Butylina, Katharina Wahl-Figlash, Martin Schepelmann, Anastasia Meshcheryakova, Peter Pietschmann |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |