Poly(I:C) Lipoamino Bundle LNPs Induce Tumor Cytotoxicity and Immune Activation with Enhanced Efficacy by Survivin Silencing
Mina Yazdi, Zahra Hasheminejad, Khouloud Hachani, Joyce Kache, Melina Grau, Barbara Wollenberg, Ali Bashiri Dezfouli, Ernst Wagner · 2026
Read Poly(I:C) Lipoamino Bundle LNPs Induce Tumor Cytotoxicity and Immune Activation with Enhanced Efficacy by Survivin Silencing by Mina Yazdi, Zahra Hasheminejad, Khouloud Hachani, Joyce Kache, Melina Grau, Barbara Wollenberg, Ali Bashiri Dezfouli, Ernst Wagner (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256650.txt.
Description
Mina Yazdi and co-authors describe in 2026 a lipid nanoparticle system that delivers poly(I:C), a synthetic molecule that both attacks tumor cells directly and wakes up the immune system. The molecule only works once it reaches receptors inside cells, so the team engineered pH-responsive carriers built from lipoamino building blocks to improve that delivery.
Their bundle-shaped carrier outperformed control formulations across several cancer cell models, killing more tumor cells at lower doses. The delivered poly(I:C) also triggered immune signals such as CXCL10 and activated immune cells taken from blood. Adding RNA that silences the survival protein survivin increased cancer cell death further, showing how one carrier can combine immune stimulation with targeted gene silencing.
Catalog record
| CREATOR | Mina Yazdi, Zahra Hasheminejad, Khouloud Hachani, Joyce Kache, Melina Grau, Barbara Wollenberg, Ali Bashiri Dezfouli, Ernst Wagner |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |