STIM/Orai-Mediated Store-Operated Ca2+ Entry in the Pathogenesis of Fibrosis: Mechanisms and Therapeutic Opportunities
Yang Yi, Md Nasim Uddin, Keira Killeen, Donald L. Gill, Yandong Zhou · 2026
Read STIM/Orai-Mediated Store-Operated Ca2+ Entry in the Pathogenesis of Fibrosis: Mechanisms and Therapeutic Opportunities by Yang Yi, Md Nasim Uddin, Keira Killeen, Donald L. Gill, Yandong Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256628.txt.
Description
Yang Yi and colleagues present a 2026 review of store-operated calcium entry, the pathway by which cells refill internal calcium stores through STIM sensor proteins and Orai membrane channels. Their focus is how this entry route goes wrong in fibrosis, the scarring process that stiffens organs such as the lung, liver, and kidney.
The review first lays out how STIM proteins detect emptied stores and open Orai channels to sustain calcium signals. It then gathers evidence that faulty entry drives fibrotic progression across major organ systems. The final sections survey drugs and strategies aimed at this pathway. Framing calcium entry as a shared driver of scarring gives researchers a common target for antifibrotic therapy.
Catalog record
| CREATOR | Yang Yi, Md Nasim Uddin, Keira Killeen, Donald L. Gill, Yandong Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |