Cervicovaginal Mycobiome Restructuring by HPV and Bacterial Community State Types in a Kazakhstani Shotgun Metagenomic Cohort: Lactobacillus iners as a Candida-Permissive Niche Associated with α-9 HPV in Cytologically Normal Women
Samat Kozhakhmetov, Almagul Kushugulova, Elizaveta Vinogradova, Aidana Rakhmankulova, Milan Terzic, Gauri Bapayeva, Gulzhanat Aimagambetova, Nazira Kamzayeva, Yevgeniy Kim, Berik Primbetov, Balkenzhe Imankulova, Kuralay Kongrtay, Nazira Kadroldinova, Makhabbat Galym, Sanimkul Makhambetova, Kadisha N · 2026
Read Cervicovaginal Mycobiome Restructuring by HPV and Bacterial Community State Types in a Kazakhstani Shotgun Metagenomic Cohort: Lactobacillus iners as a Candida-Permissive Niche Associated with α-9 HPV in Cytologically Normal Women by Samat Kozhakhmetov, Almagul Kushugulova, Elizaveta Vinogradova, Aidana Rakhmankulova, Milan Terzic, Gauri Bapayeva, Gulzhanat Aimagambetova, Nazira Kamzayeva, Yevgeniy Kim, Berik Primbetov, Balkenzhe Imankulova, Kuralay Kongrtay, Nazira Kadroldinova, Makhabbat Galym, Sanimkul Makhambetova, Kadisha N (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256560.txt.
Description
Samat Kozhakhmetov and a large team present a 2026 shotgun-sequencing study of the cervicovaginal microbial mix in 311 Kazakhstani women at routine cervical screening. Most microbiome research ignores fungi and Central Asian populations; this study covered both. Samples were typed for HPV, sorted by bacterial pattern, and checked for fungi from the same data.
Fungal makeup differed sharply by HPV status. Candida yeast showed up far more often with high-risk alpha-9 HPV types, even in women with normal cytology. Two bacterial patterns, one led by Lactobacillus iners and one by Gardnerella, tripled Candida albicans rates and showed depleted lactate and peroxide capacity. The authors cast L. iners as a permissive neighbor rather than a protector, and propose cross-kingdom signatures as candidate markers of HPV risk.
Catalog record
| CREATOR | Samat Kozhakhmetov, Almagul Kushugulova, Elizaveta Vinogradova, Aidana Rakhmankulova, Milan Terzic, Gauri Bapayeva, Gulzhanat Aimagambetova, Nazira Kamzayeva, Yevgeniy Kim, Berik Primbetov, Balkenzhe Imankulova, Kuralay Kongrtay, Nazira Kadroldinova, Makhabbat Galym, Sanimkul Makhambetova, Kadisha N |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |