INFOGEST 2.0 Protocol Applied to Animal-Derived Milk and Dairy Products: A Systematic Review of Six Years of Scientific Effort
Giuseppe De Santis, Olubukunmi Amos Ilori, Diana Marisol Abrego-Guandique, Pierluigi Plastina, Paola Tucci, Erika Cione · 2026
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Description
Giuseppe De Santis and co-authors review six years of studies using the INFOGEST 2.0 laboratory digestion protocol on milk and dairy products in a 2026 paper. This standardized bench model mimics human digestion so researchers can estimate how foods break down and release nutrients. The team analyzed fifty selected studies published since 2020.
The protocol reproduced broad digestive trends reliably, including peptide fingerprints after protein breakdown and consistently high protein digestibility. Fat and mineral release depended strongly on the dairy matrix, as in real digestion. Weaknesses included a heavy skew toward cow's milk, varied local tweaks that hurt comparability, and simple follow-on models that limit absorption claims. The authors chart a path toward dynamic, harmonized versions covering more dairy species, aiming at predicting true nutrient availability rather than describing breakdown alone.
Catalog record
| CREATOR | Giuseppe De Santis, Olubukunmi Amos Ilori, Diana Marisol Abrego-Guandique, Pierluigi Plastina, Paola Tucci, Erika Cione |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |