The Role of Vitamin D in Neuropathic Pain: Biological Mechanisms and Clinical Relevance
Mario García-Domínguez · 2026
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Description
Mario García-Domínguez authored a 2026 review of vitamin D's role in neuropathic pain, the burning, shooting pain that follows nerve injury or disease. Standard painkillers give many patients only partial relief, so adjunctive ideas draw interest. Vitamin D, beyond its bone duties, calms immune activity and protects nerves, making it a plausible modulator of pain signaling.
Observational studies repeatedly tie low vitamin D to worse neuropathic pain severity. Trials of supplementation suggest relief in some groups, such as diabetic neuropathy patients, though results vary across studies. Proposed mechanisms include quieting neuroinflammation, steadying neuron excitability, and influencing neurotransmitter pathways. The author finds the case suggestive but unproven, calling for rigorous trials to establish cause, dose, and which patients benefit, before vitamin D joins standard pain care.
Catalog record
| CREATOR | Mario García-Domínguez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |