Long Non-Coding RNAs Identified as Hub Genes by Weighted Gene Co-Expression Network Analysis in Schistosoma mansoni Following Incubation with Bothrops Snake Venoms
Marina Zenga-Carrenho, Agatha Fischer-Carvalho, Tereza Cristina Taveira-Barbosa, Pedro Jardim Poli, Vilaça Guimarães-Oliveira, Alison Felipe Alencar Chaves, Solange M. T. Serrano, Ana Carolina Tahira, Sergio Verjovski-Almeida, Murilo Sena Amaral · 2026
Read Long Non-Coding RNAs Identified as Hub Genes by Weighted Gene Co-Expression Network Analysis in Schistosoma mansoni Following Incubation with Bothrops Snake Venoms by Marina Zenga-Carrenho, Agatha Fischer-Carvalho, Tereza Cristina Taveira-Barbosa, Pedro Jardim Poli, Vilaça Guimarães-Oliveira, Alison Felipe Alencar Chaves, Solange M. T. Serrano, Ana Carolina Tahira, Sergio Verjovski-Almeida, Murilo Sena Amaral (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256390.txt.
Description
Marina Zenga-Carrenho and colleagues report a 2026 study of how snake venoms disturb gene regulation in Schistosoma mansoni, the worm behind schistosomiasis. The only drug for the disease, praziquantel, faces emerging tolerance, and venoms are an unusual hunting ground for fresh angles. Adult worms were bathed in eight Bothrops pit viper venoms at sublethal doses.
One venom shrank every measured trait, while another mainly cut egg laying. Sequencing worms exposed to two venoms revealed wide expression changes, including in long non-coding RNAs, molecules that regulate other genes. Network analysis found far more hub RNAs in males than females, and lab checks confirmed most selected candidates. The authors nominate specific hub RNAs for functional follow-up as possible drug targets in a parasite that badly needs new ones.
Catalog record
| CREATOR | Marina Zenga-Carrenho, Agatha Fischer-Carvalho, Tereza Cristina Taveira-Barbosa, Pedro Jardim Poli, Vilaça Guimarães-Oliveira, Alison Felipe Alencar Chaves, Solange M. T. Serrano, Ana Carolina Tahira, Sergio Verjovski-Almeida, Murilo Sena Amaral |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |