Use of the MOF NU-1000 as a Drug Delivery System for the Antineoplastic Drug Mitoxantrone
Daniel R. Alfonso, Francisco G. Moscoso, David Rodríguez-Lucena, Javier Roales, Carolina Carrillo-Carrión, María Victoria Cascajo-Almenara, Carlos Santos-Ocaña, José M. Pedrosa · 2026
Read Use of the MOF NU-1000 as a Drug Delivery System for the Antineoplastic Drug Mitoxantrone by Daniel R. Alfonso, Francisco G. Moscoso, David Rodríguez-Lucena, Javier Roales, Carolina Carrillo-Carrión, María Victoria Cascajo-Almenara, Carlos Santos-Ocaña, José M. Pedrosa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256363.txt.
Description
Daniel R. Alfonso and co-authors report a 2026 study loading the chemotherapy drug mitoxantrone into NU-1000, a zirconium-based metal-organic framework full of ordered pores. Such sponges can carry large drug quantities and release them at the tumor. The particles kept their crystal structure and shape after loading, and uptake reached roughly forty percent drug by weight, mostly within three hours.
A polyethylene glycol coating steadied the loaded particles in body-like fluid. The coated carrier alone barely harmed cultured cervical cancer cells, showing good compatibility. Loaded particles, though, killed cancer cells more effectively than free drug at short exposure times. The authors present NU-1000 as a promising delivery platform that combines high capacity with stability, an early step toward gentler chemotherapy dosing.
Catalog record
| CREATOR | Daniel R. Alfonso, Francisco G. Moscoso, David Rodríguez-Lucena, Javier Roales, Carolina Carrillo-Carrión, María Victoria Cascajo-Almenara, Carlos Santos-Ocaña, José M. Pedrosa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |