Neutrophils and Neutrophil Extracellular Traps in Hepatic Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Strategies
Furong Xu, Meiyan Wang, Bingxin Wang, Jian Yang, Xiaoqing Qian · 2026
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Description
Furong Xu and co-authors review liver ischemia-reperfusion injury in a 2026 paper centered on neutrophils. These white blood cells flood the liver when blood flow returns after transplant, major liver surgery, or trauma care. The injury couples energy failure in the ischemic phase with an explosive sterile inflammation once flow resumes, and no approved targeted drug yet exists.
The review maps how neutrophils are recruited and switched on, centered on the Mac-1-Syk signaling axis inside the cells. It then traces how neutrophil extracellular traps form step by step and injure the liver in several ways. Cross-talk with platelets and other liver cells amplifies an inflammation-clotting loop. The authors sort out disputes over core drug targets, flag the bottlenecks blocking clinical use, and propose a sequenced multi-target plan built around the traps.
Catalog record
| CREATOR | Furong Xu, Meiyan Wang, Bingxin Wang, Jian Yang, Xiaoqing Qian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 102 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |