The Role of Iron in Neuronal Homeostasis: A Double-Edged Sword
Bibiana Sgalletta, Francesco Agostini, Marco Bisaglia · 2026
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Description
Bibiana Sgalletta and co-authors wrote a 2026 review of iron's double role in the brain: essential nutrient and potential toxin. Neurons need iron for development, insulation of nerve fibers, and making chemical messengers. The brain guards its supply tightly through the blood-brain barrier and specialized support cells.
Too little iron early in life leaves lasting harm to thinking, movement, and behavior. Too much promotes oxidative stress, a form of cell death called ferroptosis, and inflammation, and abnormal deposits appear in Alzheimer's, Parkinson's, and several rarer diseases. The review moves from whole-body iron handling to cell-level control inside the brain, then to disease links. Inflammation is highlighted as the main channel through which excess iron injures neurons.
Catalog record
| CREATOR | Bibiana Sgalletta, Francesco Agostini, Marco Bisaglia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |