Feedback Loop of DUXAP8/miR-214-3p/KLF13 Facilitates Hepatocellular Carcinoma Progression and Serves as an Indicator of Tumor Microenvironment via Impacting Piezo1
Yifan Zhang, Xinyi Luo, Yiquan Lu, Fengjie Hao, Xiaochun Fei, Yongjun Chen, Junqing Wang · 2026
Read Feedback Loop of DUXAP8/miR-214-3p/KLF13 Facilitates Hepatocellular Carcinoma Progression and Serves as an Indicator of Tumor Microenvironment via Impacting Piezo1 by Yifan Zhang, Xinyi Luo, Yiquan Lu, Fengjie Hao, Xiaochun Fei, Yongjun Chen, Junqing Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256093.txt.
Description
Yifan Zhang and colleagues report a 2026 study of a self-reinforcing gene loop that drives liver cancer growth. The loop centers on DUXAP8, a pseudogene switched on in tumors, which sponges up a small regulatory RNA, freeing the factor KLF13, which in turn switches DUXAP8 back on. The team verified each link experimentally.
DUXAP8 activity in tumors tracked with worse clinical features in patients. Removing it slowed cancer cell growth, increased cell death in culture, and strongly suppressed tumor formation in animals. KLF13 also switched on Piezo1, a pressure-sensing channel tied to the tumor microenvironment. The authors cast the loop as both a signal of the tumor's surroundings and a possible intervention point, since breaking any link in the circle weakened the cancer's behavior.
Catalog record
| CREATOR | Yifan Zhang, Xinyi Luo, Yiquan Lu, Fengjie Hao, Xiaochun Fei, Yongjun Chen, Junqing Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |