The Dual Role of Ferroptosis in Cancer: Molecular Mechanisms, Microenvironment Crosstalk, and Precision Therapeutics
Yu Zhu, Meijia Chen, Jianglong Chen, Junjie Wang, Rujie Zhou, Yunfei Cui, Guang Li · 2026
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Description
Yu Zhu and colleagues wrote a 2026 review of ferroptosis, an iron-driven form of cell death, and its two-sided role in cancer. Many tumors escape the usual death pathway, apoptosis, and thereby resist standard drugs. Ferroptosis kills differently, through iron-fueled damage to cell membranes' fatty layers.
Triggering ferroptosis can stop some tumors outright, the review explains, yet other cancers learn to dodge it and use that escape to survive and spread. The process also talks with the tumor's surroundings, sometimes helping and sometimes hindering immune attack. New drugs designed to force ferroptosis, especially alongside existing therapies, headline the treatment section. The authors map mechanisms and crosstalk so researchers can aim these drugs precisely at resistant cancers rather than broadly.
Catalog record
| CREATOR | Yu Zhu, Meijia Chen, Jianglong Chen, Junjie Wang, Rujie Zhou, Yunfei Cui, Guang Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |