Inhibition of IGF1R in Early MMTV-Wnt1 Mammary Tumors: A Transcriptomic Analysis
Joseph J. Bulatowicz, Alexander Lemenze, Elvan Dogan, Christopher A. Galifi, Krystopher Maingrette, Quan Shang, Teresa L. Wood · 2026
Read Inhibition of IGF1R in Early MMTV-Wnt1 Mammary Tumors: A Transcriptomic Analysis by Joseph J. Bulatowicz, Alexander Lemenze, Elvan Dogan, Christopher A. Galifi, Krystopher Maingrette, Quan Shang, Teresa L. Wood (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256066.txt.
Description
Joseph J. Bulatowicz and colleagues report a 2026 mouse study of what happens inside basal-like breast tumors when a growth receptor, IGF1R, is blocked early. Basal-like cancers are aggressive and hard to treat, and their tumors oddly carry less of this receptor than other subtypes. The team used the MMTV-Wnt1 mouse model and profiled gene activity in the tumors.
Blocking the receptor changed gene expression patterns across the tumor. The analysis also revealed previously unknown subpopulations of cells living inside these early tumors. Such cell groups may respond differently to therapy, which matters for drug design. The authors propose the expression changes as biomarker candidates for future treatments. Their broader aim is to find openings against a breast cancer subtype where targeted options remain scarce.
Catalog record
| CREATOR | Joseph J. Bulatowicz, Alexander Lemenze, Elvan Dogan, Christopher A. Galifi, Krystopher Maingrette, Quan Shang, Teresa L. Wood |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |