GALNT7 promotes the malignant progression of gastrointestinal stromal tumors by regulating KIT O-GalNAc glycosylation
Jiahao Liu, Sihan Wu, Yunfei Wang, Ge Zhang, Jiehan Li, Zhen Wang, Yuhan Yin, Hao Liu, Sanfei Peng, Yang Fu · 2026
Read GALNT7 promotes the malignant progression of gastrointestinal stromal tumors by regulating KIT O-GalNAc glycosylation by Jiahao Liu, Sihan Wu, Yunfei Wang, Ge Zhang, Jiehan Li, Zhen Wang, Yuhan Yin, Hao Liu, Sanfei Peng, Yang Fu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13256011.txt.
Description
Jiahao Liu and colleagues report a 2026 study of GALNT7, an enzyme that attaches sugars to proteins, in gastrointestinal stromal tumors. These tumors run on abnormal KIT signaling, and resistance to KIT-blocking drugs remains a serious problem. The team combined bulk, protein-level, and single-cell data to find which sugar-adding enzymes matter most.
GALNT7 emerged as the hub, raised in tumors and tied to poorer progression-free survival. In cell and mouse experiments it sped tumor growth, movement, and graft formation. The mechanism ran through KIT itself: GALNT7 attached a specific sugar mark that stabilized the KIT protein and kept its growth signals on. A sugar-blocking compound reversed these effects and shrank grafts. The authors nominate GALNT7 as both a warning marker and a drug target.
Catalog record
| CREATOR | Jiahao Liu, Sihan Wu, Yunfei Wang, Ge Zhang, Jiehan Li, Zhen Wang, Yuhan Yin, Hao Liu, Sanfei Peng, Yang Fu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |