Gallic Acid Potentiates Cisplatin Response in Cervical Cancer Cells Through Coordinated Cellular and Molecular Alterations
Elif Ozan, Mehmet Cudi Tuncer, İlhan Özdemir · 2026
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Description
Elif Ozan and her two co-authors, publishing in 2026, test whether gallic acid, a plant compound, can make the chemotherapy drug cisplatin work harder against cervical cancer. Cisplatin often fails as tumors resist it, and its side effects limit the dose. Working with HeLa cancer cells in dishes, the team measured survival, cell death, gene activity, and inflammation signals for each agent alone and combined, and scored how the two interact.
The pair killed more cancer cells together than either alone, with interaction scores in the synergy range, and the mix spared non-cancer cells relatively more. Treated cells died by the orderly route of apoptosis, with the death machinery switched on and survival genes switched down, and they piled up at a checkpoint in the division cycle. Inflammation signals eased as well. The authors stress the work is dish-only and needs animal and mechanism studies next.
Catalog record
| CREATOR | Elif Ozan, Mehmet Cudi Tuncer, İlhan Özdemir |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |