The Precision Paradox in Prostate Cancer Diagnostics: Grade Migration, Risk Misclassification, and Overtreatment in the mpMRI-Targeted Biopsy Era
Andrea Micillo, Simone Steffani, Luca Orecchia, Roberto Miano, Eric Walser, Guglielmo Manenti · 2026
Read The Precision Paradox in Prostate Cancer Diagnostics: Grade Migration, Risk Misclassification, and Overtreatment in the mpMRI-Targeted Biopsy Era by Andrea Micillo, Simone Steffani, Luca Orecchia, Roberto Miano, Eric Walser, Guglielmo Manenti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13255826.txt.
Description
Andrea Micillo and co-authors write a commentary in 2026 on a paradox in prostate cancer testing. Targeted biopsies guided by MRI scans find more serious cancers and fewer harmless ones. Yet aiming almost all samples at the most suspicious spot can overstate how much high grade cancer a man truly has.
That overstatement can shift a patient's grade group and later clash with surgery findings, where grades often drop. The authors review pooled studies on grade mismatch and discuss why sampling limits cause it. They also weigh small high grade features and gene based tests that may sharpen risk calls. The piece urges care in using targeted results for watchful waiting or focal treatment choices.
Catalog record
| CREATOR | Andrea Micillo, Simone Steffani, Luca Orecchia, Roberto Miano, Eric Walser, Guglielmo Manenti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |