Epigenetic Regulation of Uterine Smooth Muscle Tumors: Histone Modifications in Uterine Fibroids and Leiomyosarcoma
Qiwei Yang · 2026
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Description
Qiwei Yang authored a 2026 review of epigenetic control in uterine smooth muscle tumors, a family spanning common harmless fibroids and rare aggressive leiomyosarcoma cancers. Both tumor types start in the same muscle layer, yet behave very differently. Genes matter, but the review focuses on histone modifications, chemical marks on the proteins that package DNA.
In fibroids, altered marks connect to hormone responsiveness and the excess tissue buildup that causes bleeding and pressure symptoms. In leiomyosarcoma, disturbed marks accompany rapid growth and unstable genetic material. The marks also interact with other regulatory systems inside the cell. Because these changes are reversible in principle, Yang argues they offer drug targets beyond standard therapy. Better mapping of the marks could eventually sharpen diagnosis and personalize treatment.
Catalog record
| CREATOR | Qiwei Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |