Silencing of USP22 promotes FGF11 degradation to attenuates renal fibrosis in diabetic kidney disease
Zhigang Wang, Chao Liu, Jing Lv, Jiping Sun, Xiaoyang Yu, Huixian Li · 2026
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Description
Zhigang Wang and colleagues study a protein pair behind kidney scarring in diabetes in a 2026 paper. Diabetic kidney disease is a leading cause of kidney failure, and its hallmark is fibrosis, or stiff scar tissue. The team used sugar-stressed kidney cells and diabetic mice fed a high-fat diet.
A growth factor called FGF11 was high in diseased kidneys, and blocking it cut cell growth and scarring. Silencing a partner protein, USP22, sped FGF11 breakdown and eased kidney injury in mice. Restoring FGF11 undid that gain. The authors propose the USP22-FGF11 pair as a drug target.
Catalog record
| CREATOR | Zhigang Wang, Chao Liu, Jing Lv, Jiping Sun, Xiaoyang Yu, Huixian Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31328 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |