Sprayable asymmetric hydrogel prevents postoperative pleural adhesions via physical and biological dual therapy

Ni Li, Zherui Shao, Nuo Cheng, Yongbin Wang, Bin Wu, Bingchuan Hu, Qinning Wang, Yanggang Dan, Yuwei Zhou, Kanghao Zhu, Renyuan Xiao, Caoyun Ju, Cong Wang, Dawei Zheng · 2026

Read Sprayable asymmetric hydrogel prevents postoperative pleural adhesions via physical and biological dual therapy by Ni Li, Zherui Shao, Nuo Cheng, Yongbin Wang, Bin Wu, Bingchuan Hu, Qinning Wang, Yanggang Dan, Yuwei Zhou, Kanghao Zhu, Renyuan Xiao, Caoyun Ju, Cong Wang, Dawei Zheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13255078.txt.

Description

Ni Li and colleagues describe a 2026 material designed to stop pleural adhesions, the fibrous bands that can form after chest surgery. Adhesions cause chronic pain, stiff lungs, and risky repeat operations. Existing barrier sheets stick poorly to wet tissue and carry no active drugs.

Their product starts as a powder that turns into an asymmetric glue-like hydrogel within twenty seconds of touching body fluids. The gel seals tissue, stops bleeding, kills bacteria, and mops up harmful oxygen radicals. Embedded fatty bubbles slowly release two agents, a small RNA and simvastatin, that together damp the fibrosis-inflammation cycle. In rats with pleural injury, treated animals developed far fewer adhesions and healed better than untreated ones.

Catalog record

CREATORNi Li, Zherui Shao, Nuo Cheng, Yongbin Wang, Bin Wu, Bingchuan Hu, Qinning Wang, Yanggang Dan, Yuwei Zhou, Kanghao Zhu, Renyuan Xiao, Caoyun Ju, Cong Wang, Dawei Zheng
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE90 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13255078

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