Cognitive and structural brain changes in ofatumumab-treated multiple sclerosis: A longitudinal study
Aurora Zanghì, Paola Sofia Di Filippo, Carlo Robusto, Maria Claudia Moretti, Carlo Avolio, Emanuele D’Amico · 2026
Read Cognitive and structural brain changes in ofatumumab-treated multiple sclerosis: A longitudinal study by Aurora Zanghì, Paola Sofia Di Filippo, Carlo Robusto, Maria Claudia Moretti, Carlo Avolio, Emanuele D’Amico (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13255068.txt.
Description
Aurora Zanghì and co-authors report a 2026 follow-up study of people with relapsing multiple sclerosis treated with ofatumumab, an antibody therapy that quiets immune attacks. Open questions remain about whether such treatment slows brain shrinkage and protects thinking in everyday care. The study enrolled 85 patients and gathered 222 MRI scans.
Brain volume loss continued during treatment yet slowed after the first year across several regions. Thinking test scores improved on average, including processing speed and both verbal and visual memory. Overall, tissue loss and thinking scores did not move together, although links appeared in patients with more disability or weaker starting scores. The authors read the pattern as neurodegeneration persisting but easing while cognition holds up.
Catalog record
| CREATOR | Aurora Zanghì, Paola Sofia Di Filippo, Carlo Robusto, Maria Claudia Moretti, Carlo Avolio, Emanuele D’Amico |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |