Tumor infiltrating B cells and tertiary lymphoid structures in pancreatic cancer prognosis and therapy
Zichen Pan, Fusheng Zhang, Cuixia Zhang, Xingyue Li, Yongsu Ma, Yinmo Yang, Xiaodong Tian · 2026
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Description
Zichen Pan and colleagues review B cells and tertiary lymphoid structures inside pancreatic tumors in a 2026 article. Pancreatic ductal adenocarcinoma is among the deadliest cancers, largely because its setting suppresses immunity so thoroughly that immunotherapy usually fails. B cells inside the tumor are a major component of that environment, and in some patients they cluster with other immune cells into lymphoid structures resembling small lymph nodes.
The evidence the review assembles is double-edged. Distinct B cell subsets pull in opposite directions, some feeding tumor progression and others strengthening anti-tumor attack. Where the lymphoid structures reach maturity, patients tend to show better prognosis and better treatment outcomes. The authors trace how these structures form, how their B cells interact with T cells, dendritic cells, and the surrounding stroma, and where the prognostic signal is strongest.
Catalog record
| CREATOR | Zichen Pan, Fusheng Zhang, Cuixia Zhang, Xingyue Li, Yongsu Ma, Yinmo Yang, Xiaodong Tian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |